产品名称
Arylsulfatase G Rabbit Polyclonal Antibody
别名
ARSG; KIAA1001; Arylsulfatase G; ASG
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22901
Human Swissprot No.
Q96EG1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96EG1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74008
Mouse Swissprot No.
Q3TYD4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TYD4
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=303631
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q32KJ9
免疫原
The antiserum was produced against synthesized peptide derived from human ARSG. AA range:251-300
特异性
Arylsulfatase G Polyclonal Antibody detects endogenous levels of Arylsulfatase G protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012],
组织表达
Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
细胞定位
Lysosome . The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. .
功能
cofactor:Binds 1 calcium ion per subunit.,PTM:N-glycosylated.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
