产品名称
TLE1 Rabbit Polyclonal Antibody
别名
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.337% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7088
Human Swissprot No.
Q04724
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q04724/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21885
Mouse Swissprot No.
Q62440
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q62440
免疫原
Synthesized peptide derived from human TLE1 AA range: 300-350
特异性
This antibody detects endogenous levels of TLE1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
In all tissues examined, mostly in brain, liver and muscle.
细胞定位
Nucleus . Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
功能
function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.,PTM:Phosphorylated, probably by CDC2. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 6 WD repeats.,subcellular location:Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif).,tissue specificity:In all tissues examined, mostly in brain, liver and muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
