产品名称
B3GL1 Rabbit Polyclonal Antibody
基因名称
B3GALNT1 B3GALT3 UNQ531/PRO1074
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8706
Human Swissprot No.
O75752
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75752/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26879
Mouse Swissprot No.
Q920V1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q920V1
Rat Gene Link
https://www.uniprot.org/uniprot/310508
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AY39
免疫原
Synthesized peptide derived from human B3GL1 AA range: 24-74
特异性
This antibody detects endogenous levels of B3GL1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described; they all encode the same protein. [provided by RefSeq, Jul 2008],
组织表达
Higher expression in heart and brain, and to a lesser extent in lung, placenta, kidney and testis. Lower expression in liver, spleen and stomach. No expression in skeletal muscle.
细胞定位
Golgi apparatus membrane; Single-pass type II membrane protein.
功能
catalytic activity:UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.,cofactor:Magnesium.,function:Transfers N-acetylgalactosamine onto globotriaosylceramide.,online information:Beta-1,3-galactosyltransferase 3,online information:Blood group antigen gene mutation database,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,polymorphism:Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and P. Genetic variation in B3GALT3 determines the P1(k) and P2(k) phenotype, which is rare and lack the capability to synthesize P antigen identified as globoside.,similarity:Belongs to the glycosyltransferase 31 family.,tissue specificity:Higher expression in heart and brain, and to a lesser extent in lung, placenta, kidney and testis. Lower expression in liver, spleen and stomach. No expression in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
