产品名称
ARRDC3 Rabbit Polyclonal Antibody
别名
ARRDC3; KIAA1376; Arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; TLIMP
蛋白名称
Arrestin domain-containing protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57561
Human Swissprot No.
Q96B67
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96B67/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=105171
Mouse Swissprot No.
Q7TPQ9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TPQ9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309945
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6TXF1
免疫原
The antiserum was produced against synthesized peptide derived from human ARRDC3. AA range:365-414
特异性
ARRDC3 Polyclonal Antibody detects endogenous levels of ARRDC3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016],
组织表达
Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow (PubMed:16269462). Strong expression in differentiated adipocytes compared to preadipocytes (PubMed:16269462). Detected in omental fat and subcutaneous fat tissue (PubMed:21982743).
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Endosome . Early endosome . Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325). .
功能
induction:By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by PMA (phorbol myristate acetate) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist).,similarity:Belongs to the arrestin family.,subcellular location:Associated with plasma membrane, as well as with endodomes and lysosomes during endocytosis.,subunit:Does not bind TXN (thioredoxin).,tissue specificity:Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
