产品名称
ARPP-21 Rabbit Polyclonal Antibody
别名
ARPP21; TARPP; cAMP-regulated phosphoprotein 21; ARPP-21; Thymocyte cAMP-regulated phosphoprotein
蛋白名称
cAMP-regulated phosphoprotein 21
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10777
Human Swissprot No.
Q9UBL0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UBL0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74100
Mouse Swissprot No.
Q9DCB4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DCB4
免疫原
The antiserum was produced against synthesized peptide derived from human ARPP21. AA range:211-260
特异性
ARPP-21 Polyclonal Antibody detects endogenous levels of ARPP-21 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
组织表达
Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).
功能
function:Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.,PTM:Isoform 1 is methylated by CARM1 in immature thymocytes.,PTM:Phosphorylation at Ser-56 favors interaction with CALM1.,similarity:Contains 1 R3H domain.,subunit:Interacts with CALM1.,tissue specificity:Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
