产品名称
Arp3 Rabbit Polyclonal Antibody
别名
ACTR3; ARP3; Actin-related protein 3; Actin-like protein 3
蛋白名称
Actin-related protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10096
Human Swissprot No.
P61158
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P61158/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74117
Mouse Swissprot No.
Q99JY9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99JY9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81732
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4V7C7
免疫原
The antiserum was produced against synthesized peptide derived from human ACTR3. AA range:369-418
特异性
Arp3 Polyclonal Antibody detects endogenous levels of Arp3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013],
组织表达
Brain,Cajal-Retzius cell,T-cell,
细胞定位
Cytoplasm, cytoskeleton . Cell projection . Nucleus . In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).
信号通路
Regulation of Actin Dynamics; Adherens_Junction; Protein_Acetylation
功能
function:Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.,similarity:Belongs to the actin family.,similarity:Belongs to the actin family. ARP3 subfamily.,subunit:Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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