产品名称
Arnt 2 Rabbit Polyclonal Antibody
别名
ARNT2; BHLHE1; KIAA0307; Aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2; Class E basic helix-loop-helix protein 1; bHLHe1
蛋白名称
Aryl hydrocarbon receptor nuclear translocator 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9915
Human Swissprot No.
Q9HBZ2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HBZ2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11864
Mouse Swissprot No.
Q61324
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61324
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25243
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q78E60
免疫原
The antiserum was produced against synthesized peptide derived from human ARNT2. AA range:21-70
特异性
Arnt 2 Polyclonal Antibody detects endogenous levels of Arnt 2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
aryl hydrocarbon receptor nuclear translocator 2(ARNT2) Homo sapiens This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013],
组织表达
Brain,Human cervix,Spleen,
信号通路
Pathways in cancer;Renal cell carcinoma;
功能
function:Specifically recognizes the xenobiotic response element (XRE).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
