产品名称
ARHGEF10 Rabbit Polyclonal Antibody
别名
ARHGEF10; KIAA0294; Rho guanine nucleotide exchange factor 10
蛋白名称
Rho guanine nucleotide exchange factor 10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9639
Human Swissprot No.
O15013
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15013/entry
Mouse Swissprot No.
Q8C033
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C033
免疫原
The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388
特异性
ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
组织表达
Amygdala,Brain,Duodenum,Prostate,Testis,Uterus,
信号通路
Regulation of Actin Dynamics; AMPK
功能
disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,function:May play a role in developmental myelination of peripheral nerves.,sequence caution:Cloning artifact.,sequence caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
