产品名称
ARHGAP23 Rabbit Polyclonal Antibody
别名
ARHGAP23; KIAA1501; Rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23
蛋白名称
Rho GTPase-activating protein 23
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57636
Human Swissprot No.
Q9P227
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9P227/entry
Mouse Swissprot No.
Q69ZH9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q69ZH9
免疫原
Synthesized peptide derived from ARHGAP23 . at AA range: 470-550
特异性
ARHGAP23 Polyclonal Antibody detects endogenous levels of ARHGAP23 protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008],
组织表达
Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.
细胞定位
cytosol,extracellular exosome,
功能
function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
