BD-PT0309

ARF6 Rabbit Polyclonal Antibody

ARF6; ADP-ribosylation factor 6

常规抗体

ARF6

ADP-ribosylation factor 6

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

382

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=382

P62330

http://www.uniprot.org/uniprotkb/P62330/entry

11845

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11845

P62331

http://www.uniprot.org/uniprot/P62331

79121

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79121

P62332

http://www.uniprot.org/uniprot/P62332

Synthesized peptide derived from ARF6 . at AA range: 30-110

ARF6 Polyclonal Antibody detects endogenous levels of ARF6 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

20kD

-20°C/1 year

Polyclonal, Rabbit,IgG

ADP ribosylation factor 6(ARF6) Homo sapiens This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008],

Ubiquitous, with higher levels in heart, substantia nigra, and kidney.

Cytoplasm, cytosol . Cell membrane ; Lipid-anchor . Endosome membrane ; Lipid-anchor . Recycling endosome membrane ; Lipid-anchor . Cell projection, filopodium membrane ; Lipid-anchor . Cell projection, ruffle . Cleavage furrow . Midbody, Midbody ring . Early endosome membrane ; Lipid-anchor . Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor . Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (PubMed:23603394). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (PubMed:23603394). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (PubMed:23603394). Recruited to the cell membrane in association with CYTH2 and ARL4C (PubMed:17398095). Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (PubMed:19948740). Myristoylation is required for proper localization to membranes: myristoylation on Lys-3 allows ARF6 to remain on membranes during the GTPase cycle (PubMed:7589240, PubMed:32103017). .

Endocytosis;Fc gamma R-mediated phagocytosis;

function:GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.,similarity:Belongs to the small GTPase superfamily.,similarity:Belongs to the small GTPase superfamily. Arf family.,subunit:Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.