产品名称
ARF4 Rabbit Polyclonal Antibody
别名
ARF4; ARF2; ADP-ribosylation factor 4
蛋白名称
ADP-ribosylation factor 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=378
Human Swissprot No.
P18085
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P18085/entry
Mouse Swissprot No.
P61750
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P61750
免疫原
The antiserum was produced against synthesized peptide derived from human ARF4. AA range:71-120
特异性
ARF4 Polyclonal Antibody detects endogenous levels of ARF4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
ADP ribosylation factor 4(ARF4) Homo sapiens This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008],
组织表达
Bone marrow,Brain,Cerebellum,Placenta,Skin,Urinary bladder,
细胞定位
Golgi apparatus. Membrane ; Lipid-anchor .
功能
caution:Was originally thought to be ARF2.,function:GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.,similarity:Belongs to the small GTPase superfamily. Arf family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
