产品名称
A-Raf Rabbit Polyclonal Antibody
别名
ARAF; ARAF1; PKS; PKS2; Serine/threonine-protein kinase A-Raf; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks
蛋白名称
Serine/threonine-protein kinase A-Raf
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=369
Human Swissprot No.
P10398
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10398/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11836
Mouse Swissprot No.
P04627
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P04627
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64363
Rat Swissprot Link
http://www.uniprot.org/uniprot/P14056
免疫原
The antiserum was produced against synthesized peptide derived from human A-RAF. AA range:276-325
特异性
A-Raf Polyclonal Antibody detects endogenous levels of A-Raf protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012],
组织表达
Predominantly in urogenital tissues.
细胞定位
intracellular,mitochondrion,cytosol,
信号通路
Regulation of Actin Dynamics; ErbB/HER; Cell Growth
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RBD (Ras-binding) domain.,subunit:Interacts with TH1L/NELFD.,tissue specificity:Predominantly in urogenital tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
