产品名称
ARA70 Rabbit Polyclonal Antibody
别名
NCOA4; ARA70; ELE1; RFG; Nuclear receptor coactivator 4; NCoA-4; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein
蛋白名称
Nuclear receptor coactivator 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8031
Human Swissprot No.
Q13772
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13772/entry
免疫原
Synthesized peptide derived from ARA70 . at AA range: 320-400
特异性
ARA70 Polyclonal Antibody detects endogenous levels of ARA70 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000. IP 1:50-200Not yet tested in other applications.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009],
组织表达
Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.
细胞定位
nucleus,autolysosome,
信号通路
Pathways in cancer;Thyroid cancer;
功能
alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving NCOA4 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas.,function:Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.,polymorphism:Polymorphisms are specific to isoform alpha. Not found in isoform beta. Could be encoded by two different genes.,subunit:Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.,tissue specificity:Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform beta is only expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
