产品名称
AR α2A Rabbit Polyclonal Antibody
别名
ADRA2A; ADRA2R; ADRAR; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR
蛋白名称
Alpha-2A adrenergic receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=150
Human Swissprot No.
P08913
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08913/entry
Mouse Swissprot No.
Q01338
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q01338
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25083
Rat Swissprot Link
http://www.uniprot.org/uniprot/P22909
免疫原
The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2A. AA range:331-380
特异性
AR α2A Polyclonal Antibody detects endogenous levels of AR α2A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008],
组织表达
Epithelium,Platelet,PNS,Testis,
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
