产品名称
AQP0 Rabbit Polyclonal Antibody
别名
MIP; AQP0; Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26
蛋白名称
Lens fiber major intrinsic protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4284
Human Swissprot No.
P30301
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30301/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17339
Mouse Swissprot No.
P51180
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51180
Rat Swissprot Link
http://www.uniprot.org/uniprot/P09011
免疫原
The antiserum was produced against synthesized peptide derived from human AQP0. AA range:95-144
特异性
AQP0 Polyclonal Antibody detects endogenous levels of AQP0 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the cortex and nucleus of the retina lens (at protein level) (PubMed:30790544). Major component of lens fiber gap junctions (PubMed:24120416).
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .
功能
disease:Defects in MIP are a cause of autosomal recessive congenital cataract [MIM:154050].,domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Water channel. May be responsible for regulating the osmolarity of the lens.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Major component of lens fiber gap junctions.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
