BD-PT0285

APS Rabbit Polyclonal Antibody

SH2B2; APS; SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS

常规抗体

SH2B2

SH2B adapter protein 2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10603

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10603

O14492

http://www.uniprot.org/uniprotkb/O14492/entry

23921

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23921

Q9JID9

http://www.uniprot.org/uniprot/Q9JID9

114203

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114203

Q9Z200

http://www.uniprot.org/uniprot/Q9Z200

Synthesized peptide derived from the Internal region of human APS.

APS Polyclonal Antibody detects endogenous levels of APS protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

67kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009],

Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines.

Cytoplasm . Cell membrane . Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.

Neurotrophin;Insulin_Receptor;

function:Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.,PTM:Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.,similarity:Belongs to the SH2B adapter family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH2 domain.,subcellular location:Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.,subunit:Interacts with several proteins including KIT/c-KIT, SHC, GRB2, EPOR, CBL/c-CBL, PDGFR, VAV1 and VAV3. Interacts with SHC through its N-terminal region, with GRB2 via the phosphorylated C-terminus and with EPOR and KIT via its SH2 domain. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts with VAV3 via its PH domain.,tissue specificity:Expressed in spleen, prostrate, testis, uterus, small intestine and skeletal muscle. Among haematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.