产品名称
TLE3 Rabbit Polyclonal Antibody
别名
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.343% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7090
Human Swissprot No.
Q04726
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q04726/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21887
Mouse Swissprot No.
Q08122
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q08122
Rat Gene Link
https://www.uniprot.org/uniprot/84424
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JIT3
免疫原
Synthesized peptide derived from human TLE3 AA range: 257-307
特异性
This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013],
功能
alternative products:Experimental confirmation may be lacking for some isoforms,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1 and TCF7L2 (By similarity). Binds FOXA2.,tissue specificity:Placenta and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
