产品名称
APC5 Rabbit Polyclonal Antibody
别名
ANAPC5; APC5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5
蛋白名称
Anaphase-promoting complex subunit 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51433
Human Swissprot No.
Q9UJX4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UJX4/entry
Mouse Swissprot No.
Q8BTZ4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BTZ4
免疫原
The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200
特异性
APC5 Polyclonal Antibody detects endogenous levels of APC5 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],
组织表达
Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga
细胞定位
Nucleus . Cytoplasm, cytoskeleton, spindle .
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;
功能
function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
