产品名称
CMIP Rabbit Polyclonal Antibody
别名
C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.345% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/80790
Human Swissprot No.
Q8IY22
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IY22/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74440
Mouse Swissprot No.
Q9D486
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D486
免疫原
Synthesized peptide derived from human CMIP AA range: 105-155
特异性
This antibody detects endogenous levels of CMIP at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],
组织表达
Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.
细胞定位
Nucleus . Cytoplasm . Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343). .
功能
developmental stage:Expressed in fetal liver.,disease:Isoform 2 expression is up-regulated in MCNS.,function:Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.,similarity:Contains 1 PH domain.,subcellular location:Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients.,subunit:Interacts with FLNA.,tissue specificity:Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
