产品名称
AOX1 Rabbit Polyclonal Antibody
别名
AOX1; AO; Aldehyde oxidase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=316
Human Swissprot No.
Q06278
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q06278/entry
Mouse Swissprot No.
O54754
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54754
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54349
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0U5
免疫原
The antiserum was produced against synthesized peptide derived from human AOX1. AA range:521-570
特异性
AOX1 Polyclonal Antibody detects endogenous levels of AOX1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008],
组织表达
Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
信号通路
Valine; leucine and isoleucine degradation;Tyrosine metabolism;Tryptophan metabolism;Vitamin B6 metabolism;Nicotinate and nicotinamide metabolism;Drug metabolism;
功能
catalytic activity:An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2).,caution:Was originally (PubMed:8248161) thought to be a xanthine dehydrogenase.,cofactor:Binds 2 2Fe-2S clusters.,cofactor:FAD.,cofactor:Molybdopterin.,similarity:Belongs to the xanthine dehydrogenase family.,similarity:Contains 1 2Fe-2S ferredoxin-type domain.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Homodimer.,tissue specificity:Abundant in liver, lower levels in lung, skeletal muscle, pancreas. Undetected in heart, brain and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
