产品名称
ANT3 Rabbit Polyclonal Antibody
别名
SLC25A6; ANT3; CDABP0051; ADP/ATP translocase 3; ADP; ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6
蛋白名称
ADP/ATP translocase 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=293
Human Swissprot No.
P12236
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P12236/entry
免疫原
The antiserum was produced against synthesized peptide derived from human SLC25A6. AA range:121-170
特异性
ANT3 Polyclonal Antibody detects endogenous levels of ANT3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013],
组织表达
Expressed in erythrocytes (at protein level).
细胞定位
Mitochondrion inner membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . The complex formed with ARL2BP, ARL2 and SLC25A6/ANT3 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity). .
信号通路
Calcium;Parkinson's disease;Huntington's disease;
功能
function:Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,miscellaneous:The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
