产品名称
AMPKγ1/2/3 Rabbit Polyclonal Antibody
别名
PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK subunit gamma-1; AMPKg; PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2; AMPK gamma2; AMPK subunit gamma-2; H91620p; PRKAG3; AMPKG3; 5'-AMP-activated protein
基因名称
PRKAG1/PRKAG2/PRKAG3
蛋白名称
5'-AMP-activated protein kinase subunit gamma-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
5571/51422/53632/
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5571
Human Swissprot No.
P54619/Q9UGJ0/Q9UGI9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P54619/entry
Mouse Gene ID
19082/108099/241113
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19082
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25520
Rat Swissprot Link
http://www.uniprot.org/uniprot/P80385
免疫原
The antiserum was produced against synthesized peptide derived from human PRKAG1/2/3. AA range:46-95
特异性
AMPKγ1/2/3 Polyclonal Antibody detects endogenous levels of AMPKγ1/2/3 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
组织表达
Fetal liver,Muscle,Testis,
细胞定位
nucleoplasm,cytosol,membrane,nucleotide-activated protein kinase complex,extracellular exosome,
信号通路
Insulin Receptor; AMPK
功能
function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase gamma subunit family.,similarity:Contains 4 CBS domains.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1 and FNIP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
