BD-PT0218

AMPKβ1 Rabbit Polyclonal Antibody

PRKAB1; AMPK; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb

常规抗体

PRKAB1

5'-AMP-activated protein kinase subunit beta-1

WB

Human,Mouse,Rat,Monkey

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5564

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5564

Q9Y478

http://www.uniprot.org/uniprotkb/Q9Y478/entry

19079

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19079

Q9R078

http://www.uniprot.org/uniprot/Q9R078

83803

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83803

P80386

http://www.uniprot.org/uniprot/P80386

The antiserum was produced against synthesized peptide derived from human AMPK beta1. AA range:147-196

AMPKβ1 Polyclonal Antibody detects endogenous levels of AMPKβ1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

38kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided

Brain,Lung,Muscle,Platelet,

nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex,

AMPK

function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit.,PTM:Phosphorylated.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1 and FNIP2.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.