产品名称
Amphiphysin I Rabbit Polyclonal Antibody
别名
AMPH; AMPH1; Amphiphysin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=273
Human Swissprot No.
P49418
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49418/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=218038
Mouse Swissprot No.
Q7TQF7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TQF7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60668
Rat Swissprot Link
http://www.uniprot.org/uniprot/O08838
免疫原
The antiserum was produced against synthesized peptide derived from human AMPH. AA range:131-180
特异性
Amphiphysin I Polyclonal Antibody detects endogenous levels of Amphiphysin I protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010],
组织表达
Neurons, certain endocrine cell types and spermatocytes.
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
信号通路
Fc gamma R-mediated phagocytosis;
功能
disease:Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms.,function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subunit:Heterodimer with BIN1. Binds SH3GLB1 and AP2A2.,tissue specificity:Neurons, certain endocrine cell types and spermatocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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