产品名称
DGCR8 Rabbit Polyclonal Antibody
别名
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)
基因名称
DGCR8 C22orf12 DGCRK6 LP4941
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.348% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54487
Human Swissprot No.
Q8WYQ5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WYQ5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/94223
Mouse Swissprot No.
Q9EQM6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQM6
免疫原
Synthesized peptide derived from human DGCR8 AA range: 467-517
特异性
This antibody detects endogenous levels of DGCR8 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus . Nucleus, nucleolus . Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994).
功能
disease:May play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR).,similarity:Contains 1 WW domain.,similarity:Contains 2 DRBM (double-stranded RNA-binding) domains.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
