产品名称
ALS Rabbit Polyclonal Antibody
别名
IGFALS; ALS; Insulin-like growth factor-binding protein complex acid labile subunit; ALS
蛋白名称
Insulin-like growth factor-binding protein complex acid labile subunit
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3483
Human Swissprot No.
P35858
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P35858/entry
Mouse Swissprot No.
P70389
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70389
免疫原
The antiserum was produced against synthesized peptide derived from human IGFALS. AA range:303-352
特异性
ALS Polyclonal Antibody detects endogenous levels of ALS protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
细胞定位
Secreted, extracellular space.
功能
function:Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.,similarity:Contains 20 LRR (leucine-rich) repeats.,subunit:Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.,tissue specificity:Plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
