BD-PT0191

Aldolase A Rabbit Polyclonal Antibody

ALDOA; ALDA; Fructose-bisphosphate aldolase A; Lung cancer antigen NY-LU-1; Muscle-type aldolase

常规抗体

ALDOA

Fructose-bisphosphate aldolase A

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

226

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=226

P04075

http://www.uniprot.org/uniprotkb/P04075/entry

11674

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11674

P05064

http://www.uniprot.org/uniprot/P05064

24189

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24189

P05065

http://www.uniprot.org/uniprot/P05065

The antiserum was produced against synthesized peptide derived from human ALDOA. AA range:1-50

Aldolase A Polyclonal Antibody detects endogenous levels of Aldolase A protein.

WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

39kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011],

Brain,Cajal-Retzius cell,Cervix,Colon carcinoma,Epithelium,Eye,Feta

Cytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, M line . In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). .

Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;

catalytic activity:D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.,disease:Defects in ALDOA are the cause of aldolase A deficiency [MIM:611881]; also known as aldoA deficiency or red cell aldolase deficiency. Aldolase A deficiency is an autosomal recessive disorder associated with hereditary hemolytic anemia.,miscellaneous:In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.,similarity:Belongs to the class I fructose-bisphosphate aldolase family.,subunit:Homotetramer.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.