产品名称
ALDH1A2 Rabbit Polyclonal Antibody
别名
ALDH1A2; RALDH2; Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II)
蛋白名称
Retinal dehydrogenase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8854
Human Swissprot No.
O94788
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O94788/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19378
Mouse Swissprot No.
Q62148
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62148
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116676
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63639
免疫原
The antiserum was produced against synthesized peptide derived from human ALDH1A2. AA range:412-461
特异性
ALDH1A2 Polyclonal Antibody detects endogenous levels of ALDH1A2 protein.
稀释度
WB 1:500 - 1:2000.IHC-p:1:50-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011],
功能
catalytic activity:Retinal + NAD(+) + H(2)O = retinoate + NADH.,function:Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
