产品名称
AKAP 2 Rabbit Polyclonal Antibody
别名
AKAP2; KIAA0920; PRKA2; A-kinase anchor protein 2; AKAP-2; AKAP-KL; Protein kinase A-anchoring protein 2; PRKA2
蛋白名称
A-kinase anchor protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
445815/11217
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=445815
Human Swissprot No.
Q9Y2D5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y2D5/entry
Mouse Swissprot No.
O54931
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54931
免疫原
The antiserum was produced against synthesized peptide derived from human AKAP2. AA range:71-120
特异性
AKAP 2 Polyclonal Antibody detects endogenous levels of AKAP 2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011],
组织表达
Brain,Epithelium,Hippocampus,Liver,Muscle,Small intestine,Trachea,
功能
caution:It is uncertain whether Met-1 or Met-3 is the initiator.,function:Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP.,miscellaneous:Can be differentially expressed as a natural AKAP2-PALM2 chimeric protein.,similarity:Belongs to the paralemmin family.,tissue specificity:Expressed in infantile heart and muscle, and fibroblasts.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
