产品名称
AKAP 14 Rabbit Polyclonal Antibody
别名
AKAP14; AKAP28; A-kinase anchor protein 14; AKAP-14; A-kinase anchor protein 28 kDa; AKAP 28; Protein kinase A-anchoring protein 14; PRKA14
蛋白名称
A-kinase anchor protein 14
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=158798
Human Swissprot No.
Q86UN6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86UN6/entry
免疫原
The antiserum was produced against synthesized peptide derived from human AKAP14. AA range:1-50
特异性
AKAP 14 Polyclonal Antibody detects endogenous levels of AKAP 14 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
组织表达
Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Binds to type II regulatory subunits of protein kinase A and anchors/targets them.,subunit:Binds to type II regulatory subunits (RII).,tissue specificity:Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
