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AK6 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT0158
产品名称
AK6 Rabbit Polyclonal Antibody
别名
TAF9; AK6; CINAP; AD-004; CGI-137; Adenylate kinase isoenzyme 6; ATP-AMP transphosphorylase 6; Coilin-interacting nuclear ATPase protein; hCINAP
类别
常规抗体
蛋白名称
Adenylate kinase isoenzyme 6
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
6880
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6880
Human Swissprot No.
Q9Y3D8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y3D8/entry
Mouse Gene ID
108143
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=108143
Mouse Swissprot No.
Q8VCP8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCP8
Rat Gene ID
373541
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=373541
Rat Swissprot No.
Q5EB68
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5EB68
免疫原
The antiserum was produced against synthesized peptide derived from human KAD6. AA range:11-60
特异性
AK6 Polyclonal Antibody detects endogenous levels of AK6 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
预测分子量
20kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
adenylate kinase 6(AK6) Homo sapiens This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
组织表达
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.
细胞定位
Nucleus, nucleoplasm. Nucleus, Cajal body. Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.
信号通路
Basal transcription factors;
功能
regulation of cell growth,?chromatin organization,?transcription,?transcription, DNA-dependent,?transcription initiation,RNA elongation,?regulation of transcription, DNA-dependent,?regulation of transcription from RNA polymerase II promoter,?transcription from RNA polymerase II promoter,?transcription initiation from RNA polymerase II promoter,RNA elongation from RNA polymerase II promoter,?protein complex assembly,?protein amino acid acetylation,regulation of cell size,?positive regulation of biosynthetic process,?regulation of catabolic process,?negative regulation of catabolic process,?response to organic substance,?regulation of specific transcription from RNA polymerase II promoter,?positive regulation of specific transcription from RNA polymerase II promoter,?positive regulation of macromolecule biosynthetic process,?positive regulation of macromolecule metabolic process,?negative regulation of macromolecule metabolic process,?positive regulation of gene expression,?regulation of cell death,?chromatin modification,?covalent chromatin modification,?histone modification,?histone acetylation,?regulation of proteolysis,positive regulation of cell growth,?positive regulation of cellular biosynthetic process,?regulation of cellular catabolic process,?negative regulation of cellular catabolic process,?regulation of cellular protein metabolic process,?negative regulation of cellular protein metabolic process,?regulation of proteasomal ubiquitin-dependent protein catabolic process,?negative regulation of proteasomal ubiquitin-dependent protein catabolic process,?regulation of cellular component size,?regulation of gene-specific transcription,?RNA biosynthetic process,?response to cytokine stimulus,cellular response to DNA damage stimulus,?regulation of growth,?regulation of protein catabolic process,?negative regulation of protein catabolic process,?regulation of apoptosis,?negative regulation of apoptosis,?regulation of programmed cell death,?negative regulation of programmed cell death,?positive regulation of gene-specific transcription,?protein amino acid acylation,?macromolecular complex subunit organization,?histone H3 acetylation,regulation of transcription,?positive regulation of cell size,?negative regulation of proteolysis,?positive regulation of transcription, DNA-dependent,?positive regulation of growth,?positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,?positive regulation of transcription,?positive regulation of transcription from RNA polymerase II promoter,?positive regulation of response to stimulus,?positive regulation of nitrogen compound metabolic process,?negative regulation of protein metabolic process,?regulation of RNA metabolic process,?positive regulation of RNA metabolic process,?chromosome organization,?negative regulation of cell death,?regulation of response to cytokine stimulus,?positive regulation of response to cytokine stimulus,?macromolecular complex assembly,?protein complex biogenesis,?response to interleukin-1,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysates from Jurkat cells, using KAD6 Antibody. The lane on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using AK6 Polyclonal Antibody

Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4°,overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

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