产品名称
AIRP Rabbit Polyclonal Antibody
别名
NT5C1B; AIRP; FKSG85; Cytosolic 5'-nucleotidase 1B; cN1B; Autoimmune infertility-related protein; Cytosolic 5'-nucleotidase IB; cN-IB
蛋白名称
Cytosolic 5'-nucleotidase 1B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93034
Human Swissprot No.
Q96P26
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96P26/entry
Mouse Swissprot No.
Q91YE9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91YE9
免疫原
The antiserum was produced against synthesized peptide derived from human NT5C1B. AA range:171-220
特异性
AIRP Polyclonal Antibody detects endogenous levels of AIRP protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008],
组织表达
Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.
信号通路
Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;
功能
catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Magnesium.,enzyme regulation:Activated by ADP.,function:Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels.,function:Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.,similarity:Belongs to the 5'-nucleotidase type 3 family.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,tissue specificity:Expressed in brain, kidney, pancreas and placenta.,tissue specificity:Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
