产品名称
PANK4 Rabbit Polyclonal Antibody
别名
Pantothenate kinase 4 (hPanK4) (EC 2.7.1.33) (Pantothenic acid kinase 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.351% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55229
Human Swissprot No.
Q9NVE7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NVE7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/269614
Mouse Swissprot No.
Q80YV4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80YV4
Rat Gene Link
https://www.uniprot.org/uniprot/171053
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q923S8
免疫原
Synthesized peptide derived from human PANK4 AA range: 8-58
特异性
This antibody detects endogenous levels of PANK4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed with higher expression in the muscle.
功能
catalytic activity:ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.,enzyme regulation:Regulated by feedback inhibition by CoA and its thioesters.,function:Plays a role in the physiological regulation of the intracellular CoA concentration.,pathway:Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 1/5.,similarity:Belongs to the type II pantothenate kinase family.,subunit:Interacts with PKM2.,tissue specificity:Ubiquitously expressed with higher expression in the muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
