产品名称
AIM2 Rabbit Polyclonal Antibody
别名
AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2
蛋白名称
Interferon-inducible protein AIM2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9447
Human Swissprot No.
O14862
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14862/entry
Mouse Swissprot No.
Q91VJ1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91VJ1
免疫原
The antiserum was produced against synthesized peptide derived from human AIM2. AA range:51-100
特异性
AIM2 Polyclonal Antibody detects endogenous levels of AIM2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008],
组织表达
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
细胞定位
Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.
信号通路
Cytosolic DNA-sensing pathway;
功能
disease:Defects in AIM2 may be a cause of microsatellite unstable colon cancers.,function:Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.,induction:By interferon gamma.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 HIN-200 domain.,subunit:Homodimer.,tissue specificity:Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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