产品名称
PASD1 Rabbit Polyclonal Antibody
别名
PAS domain-containing protein 1 (Cancer/testis antigen 63) (CT63) (OX-TES-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.352% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/139135
Human Swissprot No.
Q8IV76
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IV76/entry
免疫原
Synthesized peptide derived from human PASD1 AA range: 710-760
特异性
This antibody detects endogenous levels of PASD1 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010],
组织表达
Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).
细胞定位
[Isoform 1]: Nucleus . Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). .; [Isoform 2]: Nucleus . Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). .
功能
function:May function as a transcription factor.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,tissue specificity:Testis-specific. Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
