产品名称
AF-10 Rabbit Polyclonal Antibody
别名
MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8028
Human Swissprot No.
P55197
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P55197/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17354
Mouse Swissprot No.
O54826
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54826
免疫原
The antiserum was produced against synthesized peptide derived from human AF10. AA range:211-260
特异性
AF-10 Polyclonal Antibody detects endogenous levels of AF-10 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10(MLLT10) Homo sapiens This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],
组织表达
Expressed abundantly in testis.
功能
disease:A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein.,disease:A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 PHD-type zinc fingers.,tissue specificity:Expressed abundantly in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
