产品名称
ADNP Rabbit Polyclonal Antibody
别名
ADNP; ADNP1; KIAA0784; Activity-dependent neuroprotector homeobox protein; Activity-dependent neuroprotective protein
蛋白名称
Activity-dependent neuroprotector homeobox protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23394
Human Swissprot No.
Q9H2P0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H2P0/entry
Mouse Swissprot No.
Q9Z103
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z103
免疫原
The antiserum was produced against synthesized peptide derived from human ADNP. AA range:111-160
特异性
ADNP Polyclonal Antibody detects endogenous levels of ADNP protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.
功能
function:Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 9 C2H2-type zinc fingers.,tissue specificity:Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
