产品名称
ADK Rabbit Polyclonal Antibody
别名
ADK; Adenosine kinase; AK; Adenosine 5'-phosphotransferase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=132
Human Swissprot No.
P55263
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P55263/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11534
Mouse Swissprot No.
P55264
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P55264
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25368
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q64640
免疫原
The antiserum was produced against synthesized peptide derived from human ADK. AA range:1-50
特异性
ADK Polyclonal Antibody detects endogenous levels of ADK protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
组织表达
Widely expressed. Highest level in placenta, liver, muscle and kidney.
细胞定位
[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm .
功能
catalytic activity:ATP + adenosine = ADP + AMP.,cofactor:Binds 3 magnesium ions per subunit.,function:ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.,pathway:Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Monomer.,tissue specificity:Widely expressed. Highest level in placenta, liver, muscle and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
