产品名称
ADH7 Rabbit Polyclonal Antibody
别名
ADH7; Alcohol dehydrogenase class 4 mu/sigma chain; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase
蛋白名称
Alcohol dehydrogenase class 4 mu/sigma chain
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=131
Human Swissprot No.
P40394
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P40394/entry
Mouse Swissprot No.
Q64437
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64437
免疫原
The antiserum was produced against synthesized peptide derived from human ADH7. AA range:211-260
特异性
ADH7 Polyclonal Antibody detects endogenous levels of ADH7 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
组织表达
Preferentially expressed in stomach.
信号通路
Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;
功能
catalytic activity:An alcohol + NAD(+) = an aldehyde or ketone + NADH.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Zinc.,function:Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.,miscellaneous:There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.,subunit:Homodimer.,tissue specificity:Preferentially expressed in stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
