产品名称
Adenosine A2A-R Rabbit Polyclonal Antibody
别名
ADORA2A; ADORA2; Adenosine receptor A2a
蛋白名称
Adenosine receptor A2a
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=135
Human Swissprot No.
P29274
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P29274/entry
Mouse Swissprot No.
Q60613
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60613
免疫原
The antiserum was produced against synthesized peptide derived from human ADORA2A. AA range:120-169
特异性
Adenosine A2A-R Polyclonal Antibody detects endogenous levels of Adenosine A2A-R protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
adenosine A2a receptor(ADORA2A) Homo sapiens This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript compos
组织表达
Brain,Hippocampus,Lymph,Thymus,
细胞定位
Cell membrane ; Multi-pass membrane protein . Colocalizes with GAS2L2 at neuronal processes. .
信号通路
Calcium;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;
功能
function:Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
