产品名称
YMEL1 Rabbit Polyclonal Antibody
别名
ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)
基因名称
YME1L1 FTSH1 YME1L UNQ1868/PRO4304
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.353% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10730
Human Swissprot No.
Q96TA2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96TA2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/27377
Mouse Swissprot No.
O88967
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88967
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q925S8
免疫原
Synthesized peptide derived from human YMEL1 AA range: 136-186
特异性
This antibody detects endogenous levels of YMEL1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
组织表达
High expression in cardiac and skeletal muscle mitochondria.
细胞定位
Mitochondrion inner membrane . Mitochondrion .
功能
cofactor:Binds 1 zinc ion per subunit .,function:Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism.,similarity:In the C-terminal section; belongs to the peptidase M41 family.,similarity:In the N-terminal section; belongs to the AAA ATPase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
