产品名称
Adducin γ Rabbit Polyclonal Antibody
别名
ADD3; ADDL; Gamma-adducin; Adducin-like protein 70
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=120
Human Swissprot No.
Q9UEY8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UEY8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27360
Mouse Swissprot No.
Q9QYB5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYB5
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25230
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62847
免疫原
The antiserum was produced against synthesized peptide derived from human ADD3. AA range:431-480
特异性
Adducin γ Polyclonal Antibody detects endogenous levels of Adducin γ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
adducin 3(ADD3) Homo sapiens Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region i
组织表达
Isoform 1 is ubiquitously expressed.
细胞定位
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
功能
alternative products:Additional isoforms seem to exist,domain:Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.,function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.,PTM:Sumoylated.,similarity:Belongs to the aldolase class II family. Adducin subfamily.,subunit:Heterodimer of an alpha and a gamma subunit.,tissue specificity:Heart only expresses isoform 1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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