产品名称
ADAMTS-19 Rabbit Polyclonal Antibody
别名
ADAMTS19; A disintegrin and metalloproteinase with thrombospondin motifs 19; ADAM-TS 19; ADAM-TS19; ADAMTS-19
蛋白名称
A disintegrin and metalloproteinase with thrombospondin motifs 19
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171019
Human Swissprot No.
Q8TE59
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TE59/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=240322
Mouse Swissprot No.
P59509
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P59509
免疫原
The antiserum was produced against synthesized peptide derived from human ADAMTS19. AA range:251-300
特异性
ADAMTS-19 Polyclonal Antibody detects endogenous levels of ADAMTS-19 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008],
组织表达
Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
