产品名称
ACTR-IIA Rabbit Polyclonal Antibody
别名
ACVR2A; ACVR2; Activin receptor type-2A; Activin receptor type IIA; ACTR-IIA; ACTRIIA
蛋白名称
Activin receptor type-2A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=92
Human Swissprot No.
P27037
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P27037/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11480
Mouse Swissprot No.
P27038
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P27038
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29263
Rat Swissprot Link
http://www.uniprot.org/uniprot/P38444
免疫原
The antiserum was produced against synthesized peptide derived from human ACTR-IIA. AA range:10-59
特异性
ACTR-IIA Polyclonal Antibody detects endogenous levels of ACTR-IIA protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013],
组织表达
Mammary gland,Testis,
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Cytokine-cytokine receptor interaction;TGF-beta;
功能
catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
