BD-PT0083

AChRα5 Rabbit Polyclonal Antibody

CHRNA5; NACHRA5; Neuronal acetylcholine receptor subunit alpha-5

常规抗体

CHRNA5

Neuronal acetylcholine receptor subunit alpha-5

WB

Human,Mouse,Rat,Monkey

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1138

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1138

P30532

http://www.uniprot.org/uniprotkb/P30532/entry

110835

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110835

Q2MKA5

http://www.uniprot.org/uniprot/Q2MKA5

P20420

http://www.uniprot.org/uniprot/P20420

The antiserum was produced against synthesized peptide derived from human AChRalpha5. AA range:166-215

AChRα5 Polyclonal Antibody detects endogenous levels of AChRα5 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

53kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010],

Eye,

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

disease:Genetic variations in CHRNA5 may be associated with susceptibility to lung cancer type 2 (LNCR2) [MIM:612052].,function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta).,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.