产品名称
MS4A3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/932
Human Swissprot No.
Q96HJ5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96HJ5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/170813
Mouse Swissprot No.
Q920C4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q920C4
免疫原
Synthesized peptide derived from human MS4A3 AA range: 101-151
特异性
This antibody detects endogenous levels of MS4A3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
组织表达
Expressed specifically in hematopoietic cells and tissues.
细胞定位
Endomembrane system ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Located in the perinuclear area.
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.,function:Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).,similarity:Belongs to the MS4A family.,subcellular location:Located in the perinuclear area.,subunit:Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.,tissue specificity:Expressed specifically in hematopoietic cells and tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
