BD-PT0071

ACAT-1 Rabbit Polyclonal Antibody

ACAT1; ACAT; MAT; Acetyl-CoA acetyltransferase; mitochondrial; Acetoacetyl-CoA thiolase; T2

常规抗体

ACAT1

Acetyl-CoA acetyltransferase mitochondrial

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

38

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=38

P24752

http://www.uniprot.org/uniprotkb/P24752/entry

110446

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110446

Q8QZT1

http://www.uniprot.org/uniprot/Q8QZT1

25014

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25014

P17764

http://www.uniprot.org/uniprot/P17764

The antiserum was produced against synthesized peptide derived from human ACAT1. AA range:221-270

ACAT-1 Polyclonal Antibody detects endogenous levels of ACAT-1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

45kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009],

Adipocyte,Brain,Fetal brain cortex,

Mitochondrion .

Fatty acid metabolism;Synthesis and degradation of ketone bodies;Valine; leucine and isoleucine degradation;Lysine degradation;Tryptophan metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Terpenoid backbone biosynthesis;

catalytic activity:2 acetyl-CoA = CoA + acetoacetyl-CoA.,disease:Defects in ACAT1 are a cause of 3-ketothiolase deficiency (3KTD) [MIM:203750]; also known as alpha-methylacetoaceticaciduria. 3KTD is an inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. Urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity of this disease correlates better with the environmental or acquired factors than with the ACAT1 genotype.,enzyme regulation:Activated by potassium ions, but not sodium ions.,function:Plays a major role in ketone body metabolism.,similarity:Belongs to the thiolase family.,subunit:Homotetramer.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.