产品名称
ABHD12 Rabbit Polyclonal Antibody
别名
ABHD12; C20orf22; Monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12
蛋白名称
Monoacylglycerol lipase ABHD12
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26090
Human Swissprot No.
Q8N2K0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8N2K0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76192
Mouse Swissprot No.
Q99LR1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99LR1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=499913
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6AYT7
免疫原
The antiserum was produced against synthesized peptide derived from human ABHD12. AA range:231-280
特异性
ABHD12 Polyclonal Antibody detects endogenous levels of ABHD12 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011],
组织表达
Cerebellum,Kidney,Ovarian carcinoma,Pancreas,Testis,
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein .
功能
catalytic activity:Hydrolyzes glycerol monoesters of long-chain fatty acids.,function:Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways.,PTM:Glycosylated.,similarity:Belongs to the serine esterase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
