BD-PT0043

ABCA6 Rabbit Polyclonal Antibody

ABCA6; ATP-binding cassette sub-family A member 6

常规抗体

ABCA6

ATP-binding cassette sub-family A member 6

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

23460

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23460

Q8N139

http://www.uniprot.org/uniprotkb/Q8N139/entry

Q8K441

http://www.uniprot.org/uniprot/Q8K441

Synthesized peptide derived from ABCA6 . at AA range: 1180-1260

ABCA6 Polyclonal Antibody detects endogenous levels of ABCA6 protein.

WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

185kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008],

Widely expressed with higher expression in liver.

Golgi apparatus membrane ; Multi-pass membrane protein .

ABC transporters;

developmental stage:Expressed in fetal kidney, lung and liver.,function:Probable transporter which may play a role in macrophage lipid homeostasis.,induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in liver.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.