产品名称
AASD-PPT Rabbit Polyclonal Antibody
别名
AASDHPPT; CGI-80; HAH-P; HSPC223; x0005; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; 4'-phosphopantetheinyl transferase; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; AASD-PPT;
蛋白名称
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60496
Human Swissprot No.
Q9NRN7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NRN7/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67618
Mouse Swissprot No.
Q9CQF6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CQF6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=300328
Rat Swissprot Link
http://www.uniprot.org/uniprot/B2RYJ4
免疫原
The antiserum was produced against synthesized peptide derived from human AASDHPPT. AA range:11-60
特异性
AASD-PPT Polyclonal Antibody detects endogenous levels of AASD-PPT protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008],
组织表达
Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.
细胞定位
Cytoplasm, cytosol .
信号通路
Lysine biosynthesis;Lysine degradation;
功能
catalytic activity:CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].,cofactor:Binds 1 magnesium ion.,function:Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the P-Pant transferase superfamily. AcpS family.,subunit:Monomer. Interacts with FASN.,tissue specificity:Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
